1. •The Effects of Specific Upper Cervical Adjustments on the CD4 Counts of HIV Positive Patients
   These tests were performed by the patients independent medical center where they were under medical supervision for the regular group were dramatically increased over the counts of the control group. A 48% increase in CD4 cells was demonstrated over the six month duration of the study for the adjusted group.
   

                    -Chiropractic Research J 1994;   3 (1):   32–39

1. •The Effects of Chiropractic on the Immune System:  A Review of the Literature
   This paper outlines the many components of the mammalian immune system and the anatomical and physiological connections suggesting that the nervous system plays a role in the modulation of immune response. The few studies attempting to measure the effect of chiropractic or manipulative treatment on the immune system are reviewed. Their results suggest that chiropractic or manipulative treatment may influence T and B lymphocyte numbers, NK cell numbers, antibody levels, phagocytic activity and plasma beta-endorphin levels.
   

                    -Chiropractic Journal of Australia 1993 (Dec);   23 (4):   132–135

1. •An Overview of Neuroimmunomodulation and a Possible Correlation with Musculoskeletal System Function
   It is theorized that spinal fixations may adversely affect the immune response through somatosympathetic reflexes. Spinal manipulation can correct the spinal fixations and may eliminate the adverse affects of somatosympathetic reflexes.  Activation of these receptors can be stimulatory or inhibitory depending on the neuroactive substance. The immune system may be able to communicate with the nervous system using neuromodulators and neurohormones secreted by lymphocytes. Sympathetic innervation of lymphoid tissues is not restricted to blood vessels and smooth muscle, but directly supplies lymphocytes and blood precursor cells. It is theorized that spinal fixations may adversely affect the immune response through somatosympathetic reflexes. Spinal manipulation can correct the spinal fixations and may eliminate the adverse affects of somatosympathetic reflexes.
   

                    -J Manipulative Physiol Ther 1989;   12 (4):   289–292

1. •Vertebral Subluxation Correlated with Somatic,Visceral and Immune Complaints: An Analysis of 650 Children Under Chiropractic Care
   

The process of neurological learning or programming of the central nervous system with respect to locomotion, posture, proprioception, and body kinetics begins within a few short months after birth. Our study revealed a pattern of pelvic dysfunction correlated with numerous somatic, visceral and immune complaints. These dysfunctions should be discovered as early as possible in a child’s development to effect a correction and the relationship between these dysfunctions and ill health should be further studied.

                    -Ogi Ressel BSc, DC, DACBR(C), FICPA and Robert Rudy BSc, DC, FICPA, Journal of Vertebral Subluxation Research October 18, 2004 pp 1-23

1. •The Reflex Effects of Subluxation:   The Autonomic Nervous System
   

Recent neuroscience research supports a neurophysiologic rationale for the concept that aberrant stimulation of spinal or paraspinal structures may lead to segmentally organized reflex responses of the autonomic nervous system, which in turn may alter visceral function.

                    -Brian Budgell, D.C.   J Manipulative Physiol Ther 2000 (Feb);   23 (2):   104-106